To evaluate the expression of ras, neu nocoprotein and epidermal growth factor receptor(EGFR) on uterine cervical carcinoma, immunohistochemical staining was performed on 9 cases of dysplasia, 39 cases of carcinoma in situ(CIS), 32 cases of
microinvasive carcinoma(MIC) and 60 cases of frankly invasive carcinoma(FIC).
@ES The results obtained as follow:
@EN Ras p21 protein was positive in 29.5% of total cases, and it was very low in dysplasia lesion(25.5%) and CIS(17.9%) while it was high in MIC(31.3%) and FIC(38.9%). In CIS, parabasal cell type showed positive reaction in only 8.7%, but type
showed
60.0% positivity. Invasive carcinoma showed no significant differences between histologic types.
Expression of neu protein was high in cancerous group(around 95%) and slightly lower in dysplasia(75.0%), No differences were found depending on histologic types and stages.
EGFR was expressed in 51.8% of total cases; 12.5% of dysplasia; 54.2% of all cases of carcinoma. Keratinizing type of CIS showed highest positive reaction(90.0%), of which tendency were also noted in keratinizing type of invasvie
carcinoma(76.2%).
The results suggested that ras and EGFR could be used as a factor of prognostic value.
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